High-end aseptic filling

At the beginning of June, the International Society for Pharmaceutical Engineering (ISPE) presented the Facility of the Year Award to Boehringer Ingelheim in Biberach an der Riss, Germany. The site comprises Europe’s largest facility for the development and manufacturing of pharmaceuticals. It received the award in the “equipment innovation” category for its particularly transparent and flexible production of liquid and freeze-dried biopharmaceuticals – processed on two filling lines from Bosch Packaging Technology.


Boehringer produces on an FLC filling line and an MLD combi line. Both are suitable for filling liquid and freeze-dried products into vials. Moreover, the MLD combi line processes single and double-chamber cartridges with one chamber for the freeze-dried active ingredient and one for the solvent. The lines are equipped with the corresponding isolator technology for the aseptic production and are located in modern, glass-walled cleanrooms for maximum transparency. Additional components such as sterile filtration modules and handling units were provided by the Bosch subsidiaries Pharmatec and Moeller & Devicon.


Facing extensive restructuring work in 2008, Boehringer Ingelheim laid the foundation not only for the cooperation with Bosch, but also for the largest single line order to date for Bosch Packaging Technology’s pharmaceutical product division. “Our goal was to create a flexible production area for the manufacturing of all important biopharmaceutical dosage forms, which would meet today’s and future requirements for aseptic processing while allowing transparent and flexible production,” explains Dr. Friedrich Haefele, vice president BP Fill & Finish Germany at Boehringer Ingelheim. The manufacturing lines are organized in a U-shaped configuration, thus enabling fast response to production requirements at maximum efficiency and availability.


Stefan Neher
Deputy project leader
phone: +49 7951 402-357



  • Read more about the Facility of the Year Award 2014 here.
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